When to Take Exogenous Ketones to Optimize Your Body’s Metabolism

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Over the last few years, we have been witnessing a heightened interest in consuming exogenous ketones via different types of dietary supplements. But understanding when to take exogenous ketones has been widely debated since there is limited research on the subject.

Nevertheless, if properly applied, exogenous ketones may have several beneficial effects on your metabolism, mental acuity, and stamina. 

On top of that, these supplements allow you to put your body in a state of ketosis without actually following a strict dietary regime.

There are a few situations in which exogenous ketone supplementation should trigger the most favorable metabolic processes in your body, so feel free to check them out.

When You Experience a Lack of Mental Acuity

When You Experience a Lack of Mental Acuity

Have you ever experienced brain fog after a rich meal? To be completely honest, most of us have. The brain fog after such a meal occurs because carbohydrate-rich foods require numerous metabolic processes to distribute glucose in your body. These processes cause fluctuation in the energy levels, leaving the brain deprived of sufficient amounts of glucose which in turn causes the fog.

It’s worth noting that your brain burns a quarter of the energy that your body produces each day and one of the primary sources of energy is glucose. But the glucose doesn’t have the ability to transfer from your blood into the brain directly.

In contrast, there is no problem for ketones to bridge the blood-brain barrier to supply it with a constant flow of energy and keep you sharp regardless of your dietary habits.

This is why exogenous ketone supplementation is an effective way to provide a constant flow of fuel for your brain. Exogenous ketones are usually taken on an empty stomach to ensure they reach your brain as quickly as possible. A single scoop of your favorite exogenous ketones should be enough to give you up to 6 hours of mental boost.

But if you are in a constant state of ketosis induced by a method other than supplementation, there may not be a need to take exogenous ketones.

When You Want to Enhance Your Physical Performance

It should go without saying that your body also needs fuel if you want to optimize your exercise routine. Glycogen, a polysaccharide that also comes from carbohydrates, and oxygen are the two primary elements that influence your physical performance. But your body only keeps a limited supply of both oxygen and glycogen, which can significantly affect physical efficiency.

For example, if you run a sprint or marathon, after some time, your body will burn off all of the glycogen it has stored. When this happens, your metabolism will start using fat to generate energy or make more glycogen. Either way, oxygen is a vital component of the abovementioned processes since it provides the required fuel to keep them going.

Exogenous ketones, on the other hand, help you use the stored energy more efficiently. If you take an exogenous ketones supplement, your body won’t use up all of the glycogen in the muscles and won’t have to rely too much on fats to produce energy. On top of that, ketone supplementation allows your body to utilize much less oxygen during these metabolic processes.

It is recommended to take one scoop of exogenous ketones before a workout and half a scoop after a one-hour workout or other physical activity.

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When You Want to Enhance Your Physical Performance

When You Want to Slim Down

Weight reduction aided by exogenous ketones is one of the most sought-after benefits these dietary supplements have to offer. However, you shouldn’t expect them to be any kind of miracle substance that can help you lose excess fat overnight. However, if combined with proper diet and exercise, exogenous ketones can expedite your weight-loss efforts.

There are several mechanisms that these supplements activate to make your body leaner and slimmer. Exogenous ketones increase your insulin sensitivity, which makes your body more efficient at using carbohydrates for energy rather than storing them as fat. Also, if your glucose levels are low, ketones will burn fat to create extra energy.

Additionally, exogenous ketones increase the activity of cholecystokinin (CKK) which is a hormone responsible for your appetite. If there are fewer calories in your body, the level of CKK will consequently decrease. However, a research study has shown that when your body is in a state of ketosis the amount of CKK increases, resulting in less appetite.

Usually, a single scoop of your preferred exogenous ketones supplement should be enough to put your metabolism in a state of ketosis. But you should know that the recommended amount may vary depending on your diet and exercise routine.


Overall, figuring out when to take exogenous ketones is not as simple as you might have expected because these supplements trigger various metabolic processes in your body. We hope our information will give you a better idea of the mechanisms that can be beneficial for your mental and physical performance.

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